Fig. 5: Interactions via PD-1:PD-L1/PD-L2 and PVR/TIGIT immunosuppressive axes are weakened in response to inhibition of SCD. | Communications Biology

Fig. 5: Interactions via PD-1:PD-L1/PD-L2 and PVR/TIGIT immunosuppressive axes are weakened in response to inhibition of SCD.

From: Targeting SCD triggers lipotoxicity of cancer cells and enhances anti-tumor immunity in breast cancer brain metastasis mouse models

Fig. 5

A Overall signaling patterns between CellChat-curated pathways and cell clusters in control and SCDi-treated tumors. The relative strength reflects the sum of all normalized interactions in each pathway. Inferred B MHC-I, C MHC-II, D PD-L1, E PD-L2, F PVR, and G TIGIT signaling networks among the cell populations represented by the nodes in control and SCDi-treated tumors. The thickness of lines connecting two cell populations represents the interaction strength (i.e., thicker lines represent stronger interactions).

Back to article page