Fig. 5: GGOT elucidates key pathways, biological processes, and prognosis in disease progressions through functional and survival analysis of trigger molecules. | Communications Biology

Fig. 5: GGOT elucidates key pathways, biological processes, and prognosis in disease progressions through functional and survival analysis of trigger molecules.

From: Uncovering critical transitions and molecule mechanisms in disease progressions using Gaussian graphical optimal transport

Fig. 5

We perform GO and KEGG functional analysis for (a) GSE48452, (b) GSE2565, (c) LUAD, and (d) XJTUSepsis. Different colored edges indicate different functional relationships or biological processes, circles represent different genes, and node size indicates enrichment abundance, showing the association of genes with biological processes. Box line plots of (e) LUAD and (h) XJTUSepsis demonstrate the changes in molecular expression. The blue and yellow boxes denote normal and disease states. The survival analysis of (f) MSLN, (g) RGS20, (i) SRGN, and (j) S100A9 is performed to assess significance and understand prognosis.

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