Fig. 7: GGOT visualizes stage transport processes across disease progressions. | Communications Biology

Fig. 7: GGOT visualizes stage transport processes across disease progressions.

From: Uncovering critical transitions and molecule mechanisms in disease progressions using Gaussian graphical optimal transport

Fig. 7

The visualizations of the optimal transport map from normal to different abnormal stages using PCA embeddings, (a) GSE48452, (b) GSE2565, (c) LUAD, and (d) XJTUSepsis. The blue curves denote the normal stage, and the orange curves denote the abnormal stages. We focus on showcasing the changes near the tipping point. The Gaussian distribution changes little when away from tipping points, but the distribution changes dramatically near tipping points. These phenomena indicate the instability of the critical state and the suddenness of the deterioration.

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