Fig. 2: Extended interval in weak-before-strong synaptic tagging and capture paradigm fails to show associativity.
From: Beyond boundaries: extended temporal flexibility in synaptic tagging and capture
a WTET applied to S2 (blue circles) followed by a STET applied to S1 (red circles) at a 0.5 h interval showed associativity where both LTPs sustained at potentiated level throughout the recording period (n = 7 slices from 5 animals). b When the interval between WTET and STET increased to 3 h, the WTET induced an early-form of LTP that gradually decayed to baseline level (n = 7 slices from 5 animals). Analogue traces show typical fEPSP of S1 (red) and S2 (blue) at 15 min of baseline (dotted line), 10 min after LTP induction (dashed line), and at the end of the recording (solid line). Scale bar for all traces: 3 mV/5 ms. Three red arrows represent STET, whereas a single blue arrow represents WTET. All data are represented as mean ± SEM.
