Fig. 5: Xenobot transcripts are enriched in evolutionary older strata compared to control transcripts.

Control transcripts are all the Xenopus genes expressed in epidermal progenitor cells + multiciliate cells + alpha and beta ionocyes + goblet cells (3374). Phylostratigraphic analysis of controls transcripts, all Xenobot upregulated transcripts (1812), and transcripts uniquely upregulated in Xenobots (1450), showing Xenobot transcripts significantly more enriched in Bilateria, Eumetazoa, and Metazoa compared to controls and the unique Xenobot upregulated transcripts more enriched than all Xenobot upregulated transcripts in these evolutionarily older strata. Chi-square test, p < 0.001.