Table 2 Results of fitting of the Grel-V relationships for TRPV3-K169A mutants with one (K169A, K169A/E679Q, K169A/E682Q), or the sum of two (K169A/E679Q/E682Q), Boltzmann distributions (Function 1) for inhibition by 100 μM intracellular NASPM (Fig. 3C)
From: Molecular basis of TRPV3 channel blockade by intracellular polyamines
K169A | K169A/E679Q | K169A/E682Q | K169A/E679Q/E682Q | |
|---|---|---|---|---|
Vmid1, mV | −34.7 | −16.0 | −10.7 | −16.5 |
Z1, e | −2.38 | −2.52 | −3.13 | −2.81 |
Vmid2, mV | −36.6 | |||
Z2, e | −0.48 | |||
Net charge at the ‘ring’ position | −8 | −4 | −4 | 0 |
