Fig. 2: Structural comparison between Cbln1-GluD2 with C1ql3-BAI3 reveals radically distinct binding mode and stoichiometry.
From: Structure of the complex of C1q-like 3 protein with adhesion-GPCR BAI3
a Side view of the hexametric Cbln1 with dimeric GluD2. Cbln1 are shown in orange and GluD2 dimer is colored dark and light blue (PDB: 5KCA). b Top view of the proposed model of the 36-meric C1ql3-BAI3 NTD super-complex. C1ql3’s are shown in gray, BAI3 NTDs are colored differentially as indicated. A few representative 2D class averages of neighboring C1ql3-BAI3 NTD hexamer are shown in the figure. Scale bar in the 2D class averages represent 100 Å. c Split side view of the proposed model of the 36-meric C1ql3-BAI3 NTD super-complex.
