Fig. 5: Promoting alternative signaling pathways.
From: Parallel and convergent dynamics in the evolution of primary breast and lung adenocarcinomas
In the left panels, expression of each gene in normal breast (x-axis) and normal lung (y-axis) is plotted. In the right panels, the expression of each gene in breast cancer (x-axis) and lung cancer (y-axis) is plotted. Top panels demonstrate conversion of expression in MAPK pathway genes in breast and lung cancers compared to their normal tissue counterparts. Middle panels demonstrate changes in specific components of EGFR, RAS, and RAF signaling pathways. Note, for example, convergence on expression of EGF, NRAS, KRAS, and RRAS. Lower panels show convergence with elements of the G Coupled Protein signaling families are more similar in breast and lung cancers compared to normal breast and lung.
