Fig. 7: Niche construction – remodeling the extracellular matrix.
From: Parallel and convergent dynamics in the evolution of primary breast and lung adenocarcinomas
The tumor microenvironment is subject to complex dynamics that mix host response with cancer cell niche construction. In the left panels, expression of each gene in normal breast (x-axis) and normal lung (y-axis) is plotted. In the right panels, the expression of each gene in breast cancer (x-axis) and lung cancer (y-axis) is plotted. Common patterns of increased and decreased collagen genes and metalloproteinase genes result in a convergence of expression patterns (see Supplementary Fig. 19).
