Table 2 Transcriptional selection (defined as >4-fold increased or 75% decreased expression) is extensively observed in both tumor types
From: Parallel and convergent dynamics in the evolution of primary breast and lung adenocarcinomas
Functional annotations of genes with greater than 4-fold increased expression in BRCA and LUAD | ||
---|---|---|
Pathway name | Number of genes | p-value |
Cell Cycle | 67 | 8.9e-42 |
Cell Cycle, Mitotic | 58 | 1.9e-36 |
Cell Cycle Checkpoints | 39 | 4.7e-30 |
Mitotic Prometaphase | 27 | 1.3e-19 |
Mitotic Anaphase | 27 | 1.9e-19 |
Mitotic Metaphase and Anaphase | 27 | 2.2e-19 |
PLK1 signaling | 16 | 3.7e-19 |
Separation of Sister Chromatids | 23 | 3.7e-19 |
M Phase | 35 | 5.0e-19 |
Amplification of signal from unattached kinetochores via MAD2 inhibitory signal | 19 | 5.8e-17 |
Mitotic Spindle Checkpoint | 20 | 1.0e-16 |
EML4 and NUDC in mitotic spindle formation | 19 | 1.3e-16 |
Polo-like kinase mediated events | 9 | 1.9e-13 |
FOXM1 transcription factor network | 12 | 3.2e-13 |
APC/C-mediated degradation of cell cycle proteins | 12 | 6.0e-13 |
Regulation of mitotic cell cycle | 12 | 6.0e-13 |
Aurora B and Aurora A Signaling | 18 | 7.0e-12 |
Kinesins | 10 | 3.1e-10 |
Meiosis | 15 | 3.5e-10 |
E2F transcription factor network | 12 | 5.1e-10 |
TP53 Regulation of Cell Cycle Genes | 10 | 1.8e-09 |
Signaling by Rho GTPases | 31 | 7.8e-09 |
Progesterone Signaling | 11 | 1.5e-07 |
ATM Signaling | 6 | 1.7e-07 |
DNA Replication | 10 | 1.9e-07 |
Collagen formation | 10 | 5.7e-07 |
Golgi-to-ER retrograde transport | 11 | 6.9e-07 |
ATR signaling pathway | 7 | 7.0e-07 |
Activation of NIMA Kinases NEK9, NEK6, NEK7 | 4 | 1.3e-06 |
Activation of Matrix Metalloproteinases | 6 | 2.6e-06 |
Chromosome Maintenance | 11 | 2.7e-06 |
Extracellular matrix organization | 16 | 2.9e-06 |
DNA Repair | 17 | 3.0e-06 |
Matrix Metalloproteinases | 6 | 3.9e-06 |
Activation of ATR in response to replication stress | 6 | 1.2e-05 |
Cellular senescence | 10 | 7.1e-05 |
p53 signaling pathway | 7 | 7.2e-05 |
p73 transcription factor network | 7 | 0.0001 |
Regulation of PLK1 Activity at G2/M Transition | 7 | 0.0002 |
Homologous recombination | 5 | 0.0002 |
Nucleosome assembly | 5 | 0.0003 |
uPAR-mediated signaling | 5 | 0.0001 |
Estrogen responsive protein efp controls cell cycle | 3 | 0.001 |
Targets of C-MYC transcriptional activation | 6 | 0.001 |
Signal Transduction | 51 | 0.001 |
Generic Transcription Pathway | 29 | 0.002 |
Syndecan-1-mediated signaling events | 4 | 0.003 |
Telomere Maintenance | 6 | 0.003 |
MicroRNAs in cancer | 11 | 0.004 |
ECM-receptor interaction | 5 | 0.008 |
RNA Polymerase II Transcription | 29 | 0.009 |