Table 2 Transcriptional selection (defined as >4-fold increased or 75% decreased expression) is extensively observed in both tumor types

From: Parallel and convergent dynamics in the evolution of primary breast and lung adenocarcinomas

Functional annotations of genes with greater than 4-fold increased expression in BRCA and LUAD

Pathway name

Number of genes

p-value

Cell Cycle

67

8.9e-42

Cell Cycle, Mitotic

58

1.9e-36

Cell Cycle Checkpoints

39

4.7e-30

Mitotic Prometaphase

27

1.3e-19

Mitotic Anaphase

27

1.9e-19

Mitotic Metaphase and Anaphase

27

2.2e-19

PLK1 signaling

16

3.7e-19

Separation of Sister Chromatids

23

3.7e-19

M Phase

35

5.0e-19

Amplification of signal from unattached kinetochores via MAD2 inhibitory signal

19

5.8e-17

Mitotic Spindle Checkpoint

20

1.0e-16

EML4 and NUDC in mitotic spindle formation

19

1.3e-16

Polo-like kinase mediated events

9

1.9e-13

FOXM1 transcription factor network

12

3.2e-13

APC/C-mediated degradation of cell cycle proteins

12

6.0e-13

Regulation of mitotic cell cycle

12

6.0e-13

Aurora B and Aurora A Signaling

18

7.0e-12

Kinesins

10

3.1e-10

Meiosis

15

3.5e-10

E2F transcription factor network

12

5.1e-10

TP53 Regulation of Cell Cycle Genes

10

1.8e-09

Signaling by Rho GTPases

31

7.8e-09

Progesterone Signaling

11

1.5e-07

ATM Signaling

6

1.7e-07

DNA Replication

10

1.9e-07

Collagen formation

10

5.7e-07

Golgi-to-ER retrograde transport

11

6.9e-07

ATR signaling pathway

7

7.0e-07

Activation of NIMA Kinases NEK9, NEK6, NEK7

4

1.3e-06

Activation of Matrix Metalloproteinases

6

2.6e-06

Chromosome Maintenance

11

2.7e-06

Extracellular matrix organization

16

2.9e-06

DNA Repair

17

3.0e-06

Matrix Metalloproteinases

6

3.9e-06

Activation of ATR in response to replication stress

6

1.2e-05

Cellular senescence

10

7.1e-05

p53 signaling pathway

7

7.2e-05

p73 transcription factor network

7

0.0001

Regulation of PLK1 Activity at G2/M Transition

7

0.0002

Homologous recombination

5

0.0002

Nucleosome assembly

5

0.0003

uPAR-mediated signaling

5

0.0001

Estrogen responsive protein efp controls cell cycle

3

0.001

Targets of C-MYC transcriptional activation

6

0.001

Signal Transduction

51

0.001

Generic Transcription Pathway

29

0.002

Syndecan-1-mediated signaling events

4

0.003

Telomere Maintenance

6

0.003

MicroRNAs in cancer

11

0.004

ECM-receptor interaction

5

0.008

RNA Polymerase II Transcription

29

0.009

  1. Patterns in functions of genes upregulated demonstrate common pathways that are broadly necessary for optimizing cancer cell fitness.