Fig. 3: Lung cancer induced by TAT-CRE and AD-CRE had a comparable capacity to invade the bronchiolar space. | Communications Biology

Fig. 3: Lung cancer induced by TAT-CRE and AD-CRE had a comparable capacity to invade the bronchiolar space.

From: TAT-CRE inhalation enables tumor induction corresponding to adenoviral Cre-recombinase in a lung cancer mouse model

Fig. 3

Lung adenocarcinomas induced by TAT-CRE (n = 4, 2 males, 2 females) and AD-CRE (n = 4, 2 males, 2 females) inhalation were analyzed regarding bronchiolar invasion based on IHC stains. a, b Tumor area and microscopic lesions was determined based on Claudin-3 positive tumor lesions normalized to total lung area per slice. A tumor lesion was defined by a minimal diameter of 100 µm. c Invaded bronchiolar space was determined based on the evaluation of CC10 and SPC IHC stains, taking into account the average of all detectable bronchiolar spaces per slice. d Representative IHC stains of CC10, SPC, Claudin-3 and H&E, magnification 10x. Bars indicate 200 µm. p-values were calculated using an unpaired two-sided t-test. Data is shown as mean ± SD. P-values ≤ 0.05 are considered as significant.

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