Fig. 5: TAT-CRE induced lung tumors harbored a considerable higher fraction of endothelial cells and fibroblasts than AD-CRE induced lung tumors. | Communications Biology

Fig. 5: TAT-CRE induced lung tumors harbored a considerable higher fraction of endothelial cells and fibroblasts than AD-CRE induced lung tumors.

From: TAT-CRE inhalation enables tumor induction corresponding to adenoviral Cre-recombinase in a lung cancer mouse model

Fig. 5

a Uniform manifold approximation and projection (UMAP) representation of the integrated scRNA-seq data of TAT-CRE and AD-CRE induced lung adenocarcinoma samples (n = 1 per group, 2 males), colored by dataset (left) and by cell category (right). Each dot represents a single cell. b UMAP indicating lineage marker expression of Ptprc (immune), Epcam (epithelial), Col1a1 (fibroblasts) and Cldn5 (endothelial). c UMAP visualization of the integrated scRNA-seq data of TAT-CRE and AD-CRE induced lung adenocarcinoma samples, colored by inferred cell type. d Stacked bar plot showing the fraction per condition (TAT-CRE vs AD-CRE) among non-immune cell types: AT1 (alveolar type 1) cells, AT2 (alveolar type 2) cells, Club cells, ciliated cells, endothelial cells and fibroblasts. e UMAP representation of the integrated scRNA-seq data of epithelial cells only, colored by cell type. f Relative amount of epithelial cell types among epithelial cells identified for TAT-CRE and AD-CRE induced lung adenocarcinoma samples, respectively, with numbers indicating the corresponding absolute cell numbers. g UMAP representation of the integrated scRNA-seq data of epithelial cells only, colored by malignancy.

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