Fig. 6: Pro-tumorigenic macrophages were more abundant in TAT-CRE vs AD-CRE induced lung tumors. | Communications Biology

Fig. 6: Pro-tumorigenic macrophages were more abundant in TAT-CRE vs AD-CRE induced lung tumors.

From: TAT-CRE inhalation enables tumor induction corresponding to adenoviral Cre-recombinase in a lung cancer mouse model

Fig. 6

a UMAP representation of the integrated scRNA-seq data of immune cells only for TAT-CRE and AD-CRE induced lung adenocarcinoma samples (n = 1 per group, 2 males), colored by identified cell types. Each dot represents a single cell. b Relative amount of immune cell types among immune cells identified for TAT-CRE and AD-CRE induced lung adenocarcinoma samples, respectively, with numbers indicating the corresponding absolute cell numbers. c, d Heatmap showing the top 20 differentially expressed genes (DEGs) in macrophages and alveolar macrophages, respectively. Arrows indicate MHC-II-related and angiogenesis-related genes. e Differentially expressed MHC-II-related genes in macrophages of TAT-CRE and AD-CRE induced lung adenocarcinoma samples. f Differentially expressed angiogenesis-related genes in macrophages and alveolar macrophages of TAT-CRE and AD-CRE induced lung adenocarcinoma samples. p-values were calculated using an unpaired two-sided t-test. Data is shown as mean ± SD. P-values ≤ 0.05 are considered as significant.

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