Fig. 2: Secondary t-SNE clustering analysis of macrophages. | Communications Biology

Fig. 2: Secondary t-SNE clustering analysis of macrophages.

From: Loss of LAPTM4A inhibits M2 polarization of tumor-associated macrophages in glioblastoma, promoting immune activation and enhancing anti-PD1 therapy

Fig. 2

A Heatmap of gene expression in two subclusters of macrophages after secondary clustering; B t-SNE clustering plot of the two macrophage subclusters; C t-SNE plot showing the expression of Ccl5 and Pf4 in different subclusters; D t-SNE plot showing the expression of TAM-associated genes C1qa, C1qc, Apoe, and Trem2 in different subclusters; E Bubble plot showing the expression of genes involved in M1, M2, phagocytosis, and cytokine interaction in each TAM subtype; F GO enrichment analysis of marker genes enriched in the two TAM subclusters.

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