Fig. 1: Experimental evidence of STDP at the mf-GoC synapse.
From: Coincidence detection between apical and basal dendrites drives STDP in cerebellar Golgi cells
A Left, enlargement of the GoC microcircuit, illustrating the afferent excitatory inputs from pfs/aas and mfs onto apical and basal dendrites, respectively, and the process of dendritic integration revealed by the previous modeling work33. The illustration has been created with CorelDRAW 2019. Right, EPSCs (average of 30 individual sweeps) evoked by mf stimulation before (con-, gray traces) and 30 min after (ind-, black traces) STDP induction, with different pairing time windows (Δt = ±10, ± 25, ±50 or ±100 ms). B Left, plot shows the time course of EPSC amplitude changes (expressed as the percent change of EPSC amplitude with respect to baseline) for each Δt. The plot shows the time course of average EPSC changes (large dots), with individual recordings overlaid (small dots) per Δt (Δt = −10 ms: n = 6, N = 4, p = 0.049; Δt = −25 ms: n = 6, N = 5,; Δt = +10 ms: n = 6, N = 4, p = 0.03; Δt = +25 ms:, n = 6, N = 6, p = 0.01; Δt = −50 ms:, n = 4, N = 4, p = 0.34; Δt = −100 ms: n = 3, N = 3, p = 0.44; Δt = +50 ms: n = 6, N = 6, p = 0.92; Δt = +100 ms:, n = 3, N = 3, p = 0.13; mean ± SEM; Student’s paired t test; some standard errors are small and fall inside the dots). The arrow indicates the STDP induction time (pf-AP → mf-EPSP or mf-EPSP → pf-AP pairing, 60 times at 4 Hz). Right, STDP timing curve showing EPSC amplitude changes in individual recordings 30 min after induction (small dots), and average EPSC changes (large dots). Bars indicate mean ± SEM (some standard errors are small and fall inside the dots). Note that mf-GoC STDP is Hebbian and anti-symmetric.
