Fig. 2: Model simulations of STDP at the mf-GoC synapse.
From: Coincidence detection between apical and basal dendrites drives STDP in cerebellar Golgi cells
A Model simulations of STDP. Top traces show membrane potential changes recorded from the GoC soma during pf-AP → mf-EPSP and mf-EPSP → pf-AP pairings (Δt = −25 ms: n = 20 synapses, p = 0.007; Δt = + 25 ms: n = 20 synapses, p = 6 × 10−5; Student’s paired ttest). The lower panels show the AMPA EPSCs and [Ca2+]i changes caused by the NMDA current in basal dendrite during STDP induction (60 times at 4 Hz). B Simulated GoC membrane potential changes during STDP induction shown in false colors (bottom scale is −80 mV, top scale +40 mV). The two pictures show model simulations with pf-AP → mf-EPSP and mf-EPSP → pf-AP pairing at Δt = ± 25 ms. The STDP expression is indicated for all the synapses activated in the simulation (filled circles, st-LTP; open circles st-LTD).
