Fig. 3: STDP depends on APs elicited by pf stimulation.
From: Coincidence detection between apical and basal dendrites drives STDP in cerebellar Golgi cells
Top left, schematic representations show the three different experimental conditions used to evaluate the role pf AP in STDP induction. Bottom left, EPSCs (average of 30 sweeps) evoked by mf stimulation are shown before (con-, gray traces) and 30 min after (ind-, black traces) STDP induction. The plots show the time course of average EPSC changes (large dots), with individual recordings overlaid (small dots). The arrows indicate the STDP induction time. Orange and purple dashed lines are replotted from Fig. 1B. Right, bar graphs show the average EPSC changes for Δt = −25 ms (orange) and Δt = +25 ms (purple). A STDP induction while activating only basal dendrites (mf-AP → mf-EPSP: n = 5, N = 4, p = 0.03; mf-EPSP → mf-AP: n = 5, N = 5, p = 0.03). B STDP induction with pf stimulation replaced by positive current injections into the soma (GoC-AP → mf-EPSP: n = 5, N = 4, p = 0.29; mf-EPSP → GoC-AP: n = 5, N = 5, p = 0.69). C STDP induction with a limited number of pf-elicited APs ( < 10 APs in 60 impulses; pf-EPSP → mf-EPSP: n = 6, N = 5, p = 0.72; mf-EPSP → pf-EPSP: n = 5, N = 5, p = 0.54). Mean ± SEM; Student’s paired t test; some standard errors are small and fall inside the dots. All the illustrations have been created with CorelDRAW 2019.
