Fig. 4: STDP depends on postsynaptic [Ca2+]i changes and NMDA receptor activation.
From: Coincidence detection between apical and basal dendrites drives STDP in cerebellar Golgi cells
Left, EPSCs (average of 30 sweeps) evoked by mf stimulation are shown before (con-, gray traces) and 30 min after (ind-, black traces) STDP induction. The plots show the time course of average EPSC changes (large dots), with individual recordings overlaid (small dots). The arrows indicate the STDP induction time. Orange and purple dashed lines are replotted from Fig. 1B. Right, bar graphs show the average EPSC changes for Δt = −25 ms (orange) and Δt = +25 ms (purple). A STDP induction with 10 mM EGTA in the intracellular solution (black bar; pf-AP → mf-EPSPː n = 5, N = 5, p = 0.44; mf-EPSP → pf-AP: n = 5, N = 4, p = 0.57. B STDP induction during bath-application of NMDAR antagonists, APV and 7-Cl-Kyn (black bar; pf-AP → mf-EPSP: n = 5, N = 4, p = 0.23; mf-EPSP → pf-APː n = 5, N = 5, p = 0.24). Mean ± SEM; Student’s paired t test; some standard errors are small and fall inside the dots.
