Fig. 6: The polarity of STDP is shaped by inhibition.
From: Coincidence detection between apical and basal dendrites drives STDP in cerebellar Golgi cells
Left, EPSCs (average of 30 sweeps) evoked by mf stimulation are shown before (con-, gray traces) and 30 min after (ind-, black traces) STDP induction while omitting gabazine and strychnine from the extracellular solution. The plot shows the time course of average EPSC changes (large dots), with individual recordings overlaid (small dots; (mf-EPSP → pf-AP: n = 5, N = 5, p = 0.006; pf-AP → mf-EPSPP: n = 5, N = 5, p = 0.002; mean ± SEM; Student’s paired t test; some standard errors are small and fall inside the dots). The arrow indicates the STDP induction time. Orange and purple dashed lines are replotted from Fig. 1B. Right, bar graphs show the average EPSC changes for Δt =−25 ms (orange) and Δt = +25 ms (purple).
