Fig. 1: Cardiac changes after removal of TRPV2 from a young age.
From: TRPV2 mediates stress resilience in mouse cardiomyocytes
a Schedule of tamoxifen administration. b Expression of TRPV2 protein in tamoxifen-treated heart at 5 weeks (N = 3). c Cardiac morphology (scale bar, 5 mm). d Changes in heart-to-body weight (HW/BW) ratio (N = 7–17 mice per group). e Masson’s trichrome staining of the left ventricle. Scale bar, 50 µm. f Fibrosis percentage. g, h Changes in cross-sectional area of cardiomyocytes (n = 723–995 cells from 3 mice per group). i Representative tracing of two-dimensional transthoracic M-mode echocardiography. j–l Echocardiographic assessment of left ventricular end dimension at systole, interventricular septal thickness at end-diastole, and fractional shortening (N = 5–8 mice per group). Data are shown as mean ± standard error of the mean (SEM). *P < 0.05 between indicated groups based on Tukey–Kramer test.
