Fig. 9: Changes induced by PE administration in MCM-TRPV2-cKO mice.
From: TRPV2 mediates stress resilience in mouse cardiomyocytes
a Histological analysis after 2 weeks of PE administration. Scale bar, 5 mm. b Changes in heart-to-body weight (HW/BW) ratio (N = 6–8 mice per group). c Changes in cross-sectional area of cardiomyocytes (n = 1110–2060 cells from 3 mice per group). Centre line = median; + = mean; box limits = upper and lower quartiles, whiskers = minimum and maximum. d Fibrosis percentage (N = 3 hearts per group). e Representative tracing of two-dimensional transthoracic M-mode echocardiography. f–h Echocardiographic assessment of left ventricular diastolic dimension, interventricular septal thickness at end-diastole, and fractional shortening (N = 7–11 mice per group). *P < 0.05 vs. multiple comparisons based on Tukey–Kramer test. # P < 0.05 vs. vehicle-treated Floxed-TRPV2 based on Student’s t-test. i Representative immunoblots. (N = 3 mice) *P < 0.05 vs. multiple comparisons based on Tukey–Kramer test. Data are shown as mean ± standard error of the mean (SEM).
