Fig. 2: SSRIs toxicity on differentiating cardiomyocytes. | Communications Biology

Fig. 2: SSRIs toxicity on differentiating cardiomyocytes.

From: Selective serotonin reuptake inhibitors induce cardiac toxicity through dysfunction of mitochondria and sarcomeres

Fig. 2

a The procedure of SSRIs treatment on differentiating cardiomyocytes. b The identification of NOAEL of three SSRIs during the entire differentiation process of H1-CMs. c The ATP production of differentiating H1-CMs after SSRIs exposure (n  =  8 biological replicates). d The mitochondrial membrane potential of differentiating H1-CMs after SSRIs exposure (n  =  7 biological replicates). e–i The mitochondrial respiration levels of differentiating H1-CMs after SSRIs exposure. e Graphical representation of the mitochondrial stress test. f basal respiration, g maximal respiration, h spare respiration capacity, i ATP respiration. *indicates p < 0.05, **indicates p < 0.01, ***indicates p < 0.001, ****indicates p < 0.0001. n = 5 biological replicates for DMSO and Sertraline groups; n = 7 for Fluoxetine and Paroxetine groups.

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