Fig. 5: SSRIs toxicity on differentiating cardiac organoids. | Communications Biology

Fig. 5: SSRIs toxicity on differentiating cardiac organoids.

From: Selective serotonin reuptake inhibitors induce cardiac toxicity through dysfunction of mitochondria and sarcomeres

Fig. 5

a The procedure of SSRIs treatment on differentiating cardiac organoids. b The identification of NOAEL of three SSRIs during the entire differentiation process of cardiac organoids. c The morphology changes of cardiac organoids derived from H1-hESCs. d–h The mitochondrial respiration levels of SSRIs toxicity on differentiating cardiac organoids. d Graphical representation of the mitochondrial stress test. e Basal respiration, f maximal respiration, g spare respiration capacity, h ATP-linked respiration. *indicates p < 0.05, **indicates p < 0.01, ***indicates p < 0.001. n  =  4 biological replicates for all groups.

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