Fig. 7: Transcriptomic analysis of SSRIs toxicity in the 3D model. | Communications Biology

Fig. 7: Transcriptomic analysis of SSRIs toxicity in the 3D model.

From: Selective serotonin reuptake inhibitors induce cardiac toxicity through dysfunction of mitochondria and sarcomeres

Fig. 7

a Principal component analysis for the samples. b Heatmap indicates the overall DEG expression pattern of 2 groups of samples: P1000 (paroxetine, 1000 nM) and P0 (paroxetine, 0 nM). c Volcano plot showed the DEGs between paroxetine and control. Some representative genes are highlighted in blue in the plot. d, e GO-BP terms enrichment in paroxetine compared to control. f GO-BP terms and DEGs relationship network in paroxetine compared to control. Each yellow node (circle) represents distinct GO-BP terms, and the circle size indicates the number of differentially expressed genes in the term. The edges represent categories of GO-BP terms with different color lines. g The identification of RNA-seq was verified by qPCR. *indicates p < 0.05, **indicates p < 0.01, ***indicates p < 0.001. For qPCR, n = 6 biological replicates; for RNA-seq, n = 3.

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