Fig. 3: Disease effects on structural covariance patterns.
From: Anterior-posterior systematic deficits of cortical thickness in early-onset schizophrenia
Covariance matrices were reshaped into 10 × 10 matrices according to a 10-binned mask generated from the anterior-posterior gradient of TD controls. A Diagnosis effects on reshaped covariance. The diagnosis effect was examined by using a classic interaction linear model with group and cortical thickness as factors (FDR corrected, p < 0.05). Green dots and lines represent EOS patients and gray dots and lines represent TD controls. B Symptom effects on reshaped covariance. We used N scores of the Positive and Negative Syndrome Scale (PANSS) to quantify the severity of negative symptoms, and PANSS-P scores for positive symptoms. In the EOS group, symptom effects were examined by the interaction linear model with PANSS-P/N scores and cortical thickness as factors (FDR corrected, p < 0.05).
