Fig. 5: Transcriptomics reveal reduced immune and stress responses in 8-AG-treated rats.
From: Oral 8-aminoguanine against age-related retinal degeneration
Young, aged, and 8-AG-treated aged rats’ whole retinae were processed for transcriptomic analysis using bulk RNA-seq. The differentially expressed genes (DEGs) among aged untreated vs. young and aged 8-AG treated vs. aged untreated were identified which showed >1.5-fold changes with P values of <0.05. Significantly affected biological processes were identified by gene ontology (GO) analysis. N = 3. a, b are the biological pathways (BPs) of upregulated and downregulated DEGs, respectively, in the aged untreated vs. young rat’s whole retina. c, d are the BPs of downregulated and upregulated DEGs, respectively, in the aged 8-AG-treated vs. aged rat’s whole retina. X axis represents the percentage of genes in a gene set of certain BPs and the Y axis represents the BPs. On the right side, the labeling of all graphs lists the cellular pathways.
