Fig. 1: Growth of 84 CRC cell lines as xenografts. | Communications Biology

Fig. 1: Growth of 84 CRC cell lines as xenografts.

From: Model systems and unique biological features of high and low-grade colorectal cancer (CRC) revealed by xenografting 84 human CRC cell lines

Fig. 1

A Doubling time of 74 (of 84) CRC cell lines grown as xenografts in Balb/c nu/nu mice. Balb/c nu/nu mice were injected with 2 × 106 cells for each cell line in the right and left flanks, and tumour growth was monitored every 2 or 3 days by caliper measurement. Data shown are the mean doubling time (Dt) and standard error (SEM) of n = 2–4 tumours per cell line for which Dt could be computed (n = 74). B Doubling times of cell lines separated according to MSS (n = 45) or MSI status (n = 29). Lines represent the mean of each group, and groups were compared using a non-parametric Mann–Whitney t-test, **P < 0.005.

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