Fig. 4: HG CRC cell lines lose expression of markers of colonic epithelial cells, enterocyte and goblet cells.

A, B Immunohistochemical staining of the A colonic epithelial marker Villin (VIL1); B the enterocyte marker KRT20; and C, D the goblet cell markers C MUC2 and D PAS/Alcian Blue (AB) in n = 4 representative low-grade and n = 4 representative high-grade CRC cell line xenografts.