Fig. 7: Loss of differentiation markers in HG CRC cell lines is associated with promoter methylation. | Communications Biology

Fig. 7: Loss of differentiation markers in HG CRC cell lines is associated with promoter methylation.

From: Model systems and unique biological features of high and low-grade colorectal cancer (CRC) revealed by xenografting 84 human CRC cell lines

Fig. 7

A Heatmap of corresponding methylation changes in promoters of 519 of the 1763 genes differentially expressed between HG and LG CRC cell lines. B, C Correlation of differential promoter methylation and differential gene expression for genes with B lower expression in HG cell lines (n = 346) and C lower expression in LG cell lines (n = 173).

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