Fig. 8: Transcriptional differences between HG and LG CRC cell lines grown in vitro are retained in xenografts, PDTOs and primary CRCs. | Communications Biology

Fig. 8: Transcriptional differences between HG and LG CRC cell lines grown in vitro are retained in xenografts, PDTOs and primary CRCs.

From: Model systems and unique biological features of high and low-grade colorectal cancer (CRC) revealed by xenografting 84 human CRC cell lines

Fig. 8

A–C Pearson correlations of the magnitude of differential expression of genes between HG and LG cell lines (logFC) with the corresponding change in expression between HG versus LG A xenografts, B PDTOs and C TCGA cases. D, E Canberra clustering of D n = 95 LG and n = 9 HG transcriptionally profiled patient-derived tumour organoids39, and E n = 202 LG and n = 58 HG primary CRCs profiled by the TCGA, based on a 90 gene signature derived from the 1763 DEGs in cell lines using an elastic net approach.

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