Fig. 1: Identification of inter-protein cross-links between FcRn and IgGs. | Communications Biology

Fig. 1: Identification of inter-protein cross-links between FcRn and IgGs.

From: Identification of a direct interaction between the Fab domains of IgG antibodies and human FcRn upon IgG-FcRn complex formation

Fig. 1

A and C Identified cross-links between FcRn and the Fc-part of H-mAb (A) or C-mAb (C) are visualized on the crystal structure of FcRn in complex with Fc-YTE (PDB ID: 4N0U. HSA was omitted to simplify the figure)25. B and D Identified cross-links between FcRn and H-mAb or C-mAb are visualized onto homology models of C-mAb and H-mAb aligned with Fc-YTE in PDB structure 4N0U. Pale green: HC of FcRn, light pink: β2m, wheat: Fc-YTE and HC of C-mAb and H-mAb, light blue: LC of H-mAb and C-mAb, gray lines: identified inter-protein cross-links. α3 denotes the α3 domain on (B) and (D).

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