Fig. 3: Functional genomics heatmaps.

Relative abundances of various functional genomic analyses are shown, with samples arranged in columns organized primarily by DMM cluster (top row) and functions arranged in rows. Signals along the rows are z-scored, with mean values shown in white, values above the mean shaded in red, and values below the mean shaded in blue. HMO gene analogs for each sample are presented where signals are accumulated by KEGG, gene name, and ortholog clustering for Bifidobacterium infantis blon genes organized into the HMO utilization clusters H1-H5 and Urease. The species contributing the most to the HMO utilization signals for each sample were tracked and the grouping is shown above; C1 HMO genes are most often coming from B. breve, C2 genes are frequently coming from B. longum, and C3 HMO genes primarily originate from species belonging to Clostridia, Bacilli, and Gammaproteobacteria. Virulence factors and Antimicrobial Resistance genes are seen to be more abundant in C3. Sialidases and fucosidases are more abundant in C2 and C1.