Fig. 1: Spatially resolved single-cell transcriptomic landscape of the developing mouse ovary. | Communications Biology

Fig. 1: Spatially resolved single-cell transcriptomic landscape of the developing mouse ovary.

From: Spatiotemporal and single-cell atlases to dissect regional specific cell types of the developing ovary

Fig. 1

a Schematic diagram of the experimental workflow and analysis for single-cell RNA-seq and spatial transcriptomic data. b UMAP projection of 50,655 cells (divided into 11 clusters) from 12 pooled samples of ovaries, colored by cell type. BPG, bipotential pregranulosa cells; Endo, endothelial cells; EPG&Epi, epithelial pregranulosa cells and epithelial cells; FGC, female germ cells; pMesenchyma, proliferative mesenchyma. c Heatmap of cell type-specific marker genes. d The percentage of ovarian cells classified by developmental stages. Source data are provided in Supplementary Data 1. e UMAP projection of single-cell transcriptomes colored by developmental stage from E11.5 to PD 90. E11.5, embryonic day 11.5; PD90, postnatal day 90. f Spatial spots clustered by gene expression and labeled by tissue anatomical compartment for eight developmental stages (Different colors represent distinct spatial spots clusters).

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