Fig. 2: Molecular diversity and developmental trajectory of female germ cells. | Communications Biology

Fig. 2: Molecular diversity and developmental trajectory of female germ cells.

From: Spatiotemporal and single-cell atlases to dissect regional specific cell types of the developing ovary

Fig. 2

a Visualization of FGC subclusters using UMAP. RA, retinoic acid. b Heatmap showing the marker genes of each female germ cell subcluster. Source data are provided in Supplementary Data 1. c Pseudotime trajectory of female germ cells analyzed by Monocle. d Expression of representative genes along pseudotime trajectory. e Heatmap representing the expression dynamics of 2 gene sets with increased or reduced expression at the cell state 1 (follicular oocyte) and cell state 2 (meiotic oocyte). f Visualization of E18.5 female germ cell subclusters and marker genes using UMAP. Stage 1: Stage 1 oocyte; Stage 2: Stage 2 oocyte. g Volcano plot showing the significantly differentially expressed transcripts in the Stage 2 compared with the Stage 1. h Immunofluorescence co-staining for the XDH and DDX4 in ovaries at E18.5. The scale bars represent 100 μm.

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