Fig. 5: Computational simulation of resonance and oscillation using the KCNQ model.
From: Kcnq (Kv7) channels exhibit frequency-dependent responses via partial inductor-like gating dynamics
a Simulated currents using the KCNQ model in response to depolarizing voltage steps of 10 mV for 3 s from −70 to −10 mV by NEURON simulator. Holding potential is −80 mV. b Simulated currents using the KCNQ model in response to a square depolarizing voltage step (10 mV) from −30 mV. c Conductance changes in response to a depolarizing voltage step from −30 mV in the KCNQ model. d Time course of a gating variable (activation and deactivation, m) in response to depolarizing voltage steps. e Input chirp current. f Simulated voltage response to the chirp current input in the KCNQ model. g KCNQ conductance relative to the baseline in the KCNQ model. h (upper) Step current inputs applied to the KCNQ model. (lower) Simulated membrane potentials for individual current steps.
