Fig. 6: Computational simulation of resonance and oscillation using the KCNQ model with rapid ion channel inactivation.
From: Kcnq (Kv7) channels exhibit frequency-dependent responses via partial inductor-like gating dynamics
a Simulated currents using the KCNQ channel with rapid inactivation and recovery (KCNQinactivation) model in response to depolarizing voltage steps same with those in Fig. 5a. b Simulated current using the KCNQinactivation model in response to a square depolarizing voltage step (10 mV) from −30 mV. c Conductance changes in response to a depolarizing voltage step from −30 mV in the KCNQinactivation model. d Time courses of gating variables (activation and deactivation, m; inactivation, h) in response to the depolarizing voltage step. e Input chirp current. f Simulated voltage response to the chirp current input in the KCNQinactivation model. g Conductance relative to baseline in the KCNQinactivation model. h (upper) Step current inputs applied to the KCNQinactivation model. (lower) Simulated membrane potentials for individual current steps. Membrane potential oscillations were generated in the KCNQinactivation model at depolarized membrane potentials.
