Fig. 2: Analysis of spatial clusters and cellular dynamics in bone fracture healing.

A UMAP visualization of data integrated via Harmony, displaying 27 distinct spatial clusters, each colored differently to represent various cell populations within the fracture healing tissue. B Hierarchy heatmap plot displaying gene expression profiles across the identified spatial clusters. Clusters were nomenclatured via the GPTCelltype package. C Spatial plots depicting the distribution of major spatial clusters on Day 0, Day 5, and Day 15 of bone healing in a mouse femur fracture model.