Fig. 6: Network of DE genes with highly variable RNA expression (VE/DE genes). | Communications Biology

Fig. 6: Network of DE genes with highly variable RNA expression (VE/DE genes).

From: Human alveolar macrophage response to Mycobacterium tuberculosis: immune characteristics underlying large inter-individual variability

Fig. 6

These VE/DE genes (n = 324) were identified in the 28 HAMs after M.tb infection across all time points. Standard pathway enrichment program, Ingenuity Pathway Analysis (IPA) (https://www.qiagenbioinformatics.com/products/ingenuity-pathway-analysis/), generates a top scoring gene network with IL1B, UBD, STAT1, and IRF1 as key hub genes. STAT1 and IRF1 co-operatively bind to the promoter of IDO1, another hub gene, which is also highlighted (fully annotated network is depicted in Supplementary Fig. 3). These key proteins are highlighted in red.

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