Fig. 7: Heatmap of correlations between secreted protein levels (y-axis, n = 27) in control and M.tb-infected HAM incubations at 2 h post M.tb infection versus cellular VE mRNAs 24 h post M.tb (x-axis, n = 324). | Communications Biology

Fig. 7: Heatmap of correlations between secreted protein levels (y-axis, n = 27) in control and M.tb-infected HAM incubations at 2 h post M.tb infection versus cellular VE mRNAs 24 h post M.tb (x-axis, n = 324).

From: Human alveolar macrophage response to Mycobacterium tuberculosis: immune characteristics underlying large inter-individual variability

Fig. 7

This heatmap illustrates potential effects of early secreted proteins on subsequent mRNA levels at 24 h, indicating potential autocrine/paracrine effects. A clear pattern of enhanced correlation of proteins (e.g., CCL3,4, CSF2, CXCL5,10, IL6) with mRNA expression encoded by several VE gene transcripts (e.g., IRF1, IFI6) is visible, highlighted in the lower expanded sections on the left and right. However, the same proteins display the opposite trend with higher correlations in the control cells (e.g., C1RL, CSF1, CCL24) (gene transcripts in the lower middle section). Other proteins do not show such a pattern (e.g., IL10) or even opposite correlations throughout (e.g., IL13, IL7, and IL19). All data are in Supplementary Table 5, including all correlations between 2 h protein levels and 2, 24, and 72 h mRNA levels). For a high-resolution version of the top of figure inset, please see Supplementary Fig. 7.

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