Fig. 3: Focal amplification drives TFAP2A expression. | Communications Biology

Fig. 3: Focal amplification drives TFAP2A expression.

From: Super-enhancers orchestrate transcriptional dysregulation and metabolic reprogramming in uveal melanoma

Fig. 3

A Representative images of TFAP2A immunofluorescence staining are shown at 20x magnification for UM and normal control samples. B TFAP2A immunofluorescence staining of normal and UM tissues. C TFAP2A RNA expression was measured in UM cell lines using real-time PCR. *P < 0.05, **P < 0.01, ***P < 0.001. D RNA expression analysis of TFAP2A expression in the TCGA-UM cohort. The samples were classified according to TFAP2A copy number. E Correlations between TFAP2A expression and copy number in the TCGA cohort of UM samples (Spearman correlation, p < 0.001). F Multigene analysis of UM-specific oncogenes as well as TFAP2A amplification was shown using cBioPortal.

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