Fig. 4: TFAP2A knockdown suppresses UM tumour growth. | Communications Biology

Fig. 4: TFAP2A knockdown suppresses UM tumour growth.

From: Super-enhancers orchestrate transcriptional dysregulation and metabolic reprogramming in uveal melanoma

Fig. 4

A CCK8 analysis of OMM2.3 and 92.1 cells transfected with the indicated siRNA against TFAP2A. B Western blot analysis of TFAP2A expression in cells stably transfected with the indicated sgRNAs. GAPDH was used as a loading control. C CCK8 analysis of OMM2.3 and 92.1 cells stably transfected with the indicated sgRNAs against TFAP2A. D In vivo tumour formation by OMM2.3 and TFAP2A-KD cells. K‒M curves for the sgNC and sgTFAP2A groups. E IVIS signals in the control and TFAP2A depletion groups. *P < 0.05, **P < 0.01, **P < 0.001.

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