Fig. 5: Transcriptional analysis revealed key metabolic changes after TFAP2A depletion. | Communications Biology

Fig. 5: Transcriptional analysis revealed key metabolic changes after TFAP2A depletion.

From: Super-enhancers orchestrate transcriptional dysregulation and metabolic reprogramming in uveal melanoma

Fig. 5

A Volcano plot of gene expression in OMM2.3 sgNC and TFAP2A-KD cells. B Venn diagram of DEGs (downregulated and upregulated genes) and ChIP-seq TFAP2A targets. C Pathway analysis of cells stably transfected with the indicated sgRNA against TFAP2A. D KEGG analysis of TFAP2A expression in cells stably transfected with sgNC and TFAP2A sgRNAs. E Network combining the GSEA results in the sgNC and sgTFAP2A cells. F Representative ridge plot of significant pathways in the sgNC and sgTFAP2A cells.

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