Fig. 6: TFAP2A orchestrates super enhancer activity. | Communications Biology

Fig. 6: TFAP2A orchestrates super enhancer activity.

From: Super-enhancers orchestrate transcriptional dysregulation and metabolic reprogramming in uveal melanoma

Fig. 6

A H3K27ac signal in the super enhancer (SE) and typical enhancer (TE) regions in OMM2.3 cells, as revealed by ROSE analysis. B Boxplots of SE- and TE-associated gene expression in OMM2.3 cells. C TFAP2A-associated gene expression in the TE and SE regions in OMM2.3 cells. RNA expression was normalized using FPKM. D IGV plot showing that SLC7A8-SE regions were enriched in the H3K27ac/H3K4me1 signal and in TFAP2A and EP300 binding sites. E Pancancer analysis showing that the expression of SLC7A8 was the highest in the UM dataset. *P < 0.05, **P < 0.01, ***P < 0.001. ****P < 0.0001.

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