Fig. 7: Inhibition of TFAP2A compromises metabolic reprogramming in UM cells. | Communications Biology

Fig. 7: Inhibition of TFAP2A compromises metabolic reprogramming in UM cells.

From: Super-enhancers orchestrate transcriptional dysregulation and metabolic reprogramming in uveal melanoma

Fig. 7

A, B OMM2.3 and 92.1 cells were selected and cultured in fresh medium for 24 h. Subsequently, glucose uptake, lactate secretion, and glutamine consumption were analysed and normalized. C Heatmap showing the amounts of lipid metabolites in the control and TFAP2A-depleted OMM2.3 samples. Gas chromatography‒mass spectrometry (GC‒MS) was used to collect intracellular metabolites from TFAP2A wild-type and KD cells (n = 4 biological replicates). D Heatmap showing the amounts of amino acid metabolites in the control and TFAP2A-depleted OMM2.3 samples (n = 4). E The overall schematic diagram of the study. *P < 0.05, **P < 0.01, ***P < 0.001.

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