Fig. 4: Cholesterol metabolites and secreted proteins play a key role in inter-organ communication for warm acclimation. | Communications Biology

Fig. 4: Cholesterol metabolites and secreted proteins play a key role in inter-organ communication for warm acclimation.

From: Metabolic acclimation to warming links unexpected immune activation and sexual dimorphism attenuation in Xenopus tropicalis

Fig. 4

A Partial metabolic network related to the enterohepatic circulation of bile acid. Gene expression is shown as the z-score of FPKM. Significant differential gene expression was detected in at least one condition B Cross-talk between liver, intestine, and skeletal muscle mediated by bile acid. C Generalized steps and schematic framework for identification of the inter-organ cross-talk mediated by secreted protein, and showing the liver-small intestine interaction as an example. D Distribution of significance score for all hepatic genes and secreted protein genes across all small intestinal gene expression. Insulin-like growth factor-related genes (indicated by arrow) were identified as top-ranked. E Heatmap of correlation between the expression of hepatic Igf1 and organ weight. *FDR adjusted p < 0.05, **<0.01, ***<0.001. F Distribution of significance score for all hepatic genes and secreted protein genes across all small intestinal gene expression. Insulin-like growth factor-related genes (indicated by arrow) were identified as top-ranked. All experiments were conducted based on six biological replicates in each temperature-treated group with male:female = 3:3 (except Cool-switched group, which is 4:2).

Back to article page