Fig. 6: Working model for the mechanism of action of estradiol, leading to pausing of microtubule growth.
From: Estradiol pauses microtubule growth without increased incidence of catastrophe events
Schematic of the proposed step-by-step mechanism for estradiol-based stalling of microtubule growth: Step 1: Estradiol complexes with free tubulin. Step 2: Estradiol–tubulin complex incorporates into the growing microtubule tip. Step 3: The incorporated estradiol–tubulin complex slows the growth of its associated protofilament, leading to stagnation of microtubule growth.
