Table 1 Tabulated form of in vitro activity of the BZ1 and BZ1-I against different Old and New World strains and species of Leishmania intracellular amastigotes with different incubation times
Compounds and reference drugs | Leishmania donovani (MHOM/IN/80/DD8) | Leishmania donovani (MHOM/IN/80/DD8) | Leishmania donovani (MHOM/SD/62/1S-CL2D, LdBOB) | |||||
|---|---|---|---|---|---|---|---|---|
Incubation period with compounds | 96 h incubation | 72 h incubation | ||||||
IC50 (µM) [mean ± SD] | Selectivity | IC50 (µM) [mean ± SD] | Selectivity | IC50 (µM) [mean ± SD] | Selectivity | |||
HEK-293 cells | THP-1 cells | HEK-293 cells | THP-1 cells | THP-1 cells | ||||
BZ1 | 0.59 ± 0.13 | >33.72 | >33.89 | 0.78 ± 0.27 | >25.51 | >25.64 | 4.40 ± 0.12 | >11.76 |
BZ1-I | 0.40 ± 0.38 | >24.11 | >49.12 | 0.45 ± 0.28 | >44.22 | >44.44 | 4.26 ± 0.24 | >11.49 |
Amphotericin B | 0.20 ± 0.02 | 47.61 | 10.24 | 0.60 ± 0.18 | 19.38 | 4.16 | – | – |
Miltefosine | 2.54 ± 0.57 | 15.66 | >7.87 | 3.78 ± 0.73 | 10.52 | >5.29 | – | – |
