Fig. 3: Astrocytes density in PTRC mice.
From: A novel model of light-induced middle cerebral artery occlusion and recanalization in mice
a A representative brain slice highlighted the 5 ROIs identified for the astrocytes analysis. Scale bar 1 mm. Representative confocal field of views of each of the ROIs. Scale bar, 50 µm. b The graph shows the density (mean ± SEM) of GFAP-positive cells in the 5 ROIs for PTRC group n = 6 (IC = 63 ± 2; IBZIL = 409 ± 18; RZIL = 111 ± 8; IBZCL = 147 ± 17; ICCL = 82 ± 6). *p value based on one-way ANOVA followed by Tukey’s post hoc test for the intragroup statistical analysis (IC vs IBZIL p < 0.0001; IBZIL vs RZIL p < 0.0001; IBZIL vs IBZCL p < 0.0001; IBZIL vs ICCL p < 0.0001; IBZCL vs ICIL p = 0.0003; ICCL vs IBZIL p = 0.007). c The graph shows the density (mean ± SEM) of GFAP-positive cells in the 5 ROIs normalized by the Sham group for both experimental groups (in green PT n = 6 and in blue PTRC n = 6). *p value based on two-way ANOVA followed by a post hoc Sidak’s HSD test for the intergroup statistical analysis (PT vs PTRC IBZIL p < 0.0001). IC ischemic core, IBZIL ischemic border zone ipsi-lateral, RZIL remote zone ipsi-lateral, IBZCL ischemic border zone contra-lateral, ICCL ischemic core contra-lateral.
