Fig. 2: DNMT and HDAC co-inhibition synergistically derepresses TEs. | Communications Biology

Fig. 2: DNMT and HDAC co-inhibition synergistically derepresses TEs.

From: Cancer cell type-specific derepression of transposable elements by inhibition of chromatin modifier enzymes

Fig. 2

a Number of differentially expressed TE loci induced by CMEi in GP5d, OE19 and LNCaP-1F5 cells. TE loci that meet the threshold criteria of log2FC > 1.5 and adjusted p < 0.05 compared to vehicle-treated cells are considered as differentially expressed (DESeq2). b The proportion of derepressed TE loci by CMEi belonging to major TE classes in GP5d, OE19, and LNCaP-1F5 cells. Derepressed TE loci were labeled by TE class and their counts presented as percentage of total. Numbers represent total derepressed TE loci. c Top seven intersecting sets of derepressed individual TE loci from six different CMEi in GP5d and OE19 cells. The bar plot shows the number of derepressed TE loci and the matrix below the bar plot indicates CME inhibition represented by each bar. d Overlap of derepressed individual TE loci by CMEi in LNCaP-1F5 cells. Source data are provided as Supplementary Data 11.

Back to article page