Fig. 3: Exosomal miR-1911-5p enhances cisplatin resistance in GC by inhibiting ferroptosis. | Communications Biology

Fig. 3: Exosomal miR-1911-5p enhances cisplatin resistance in GC by inhibiting ferroptosis.

From: Exo-miR-1911-5p regulates ferroptosis to promote macrophages M2 polarization-mediated gastric cancer cisplatin resistance via MYB/AKR1B10/ACC

Fig. 3

A Relative viability of GC cells co-cultured with exo-mimics/inhibitor exposed to cisplatin at the indicated concentrations (n  =  3); B The IC50 of GC cells treated with cisplatin; C, D Expression of apoptosis-related proteins detected by Western blot (n  =  3); E Cell viability of GC cells regulated by cell death inhibitors (Z-VAD-FMK, Nec-1, Fer-1) in response to DDP treatment (n  =  3); F–I The phenotype of ferroptosis modulated by exo-miR-1911-5p (F Lipid peroxidation product MDA; G Lipid ROS; H GSH/GSSG ratio; I Fe²⁺) (n  =  3); J Electron microscopy used to view mitochondria in GC cells. Representative of at least 3 experiments, data displayed as mean ± SD. ****p  <  0.0001, ***p  <  0.001, **p  <  0.01, *p  <  0.05.

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